United States securities and exchange commission logo May 6, 2022 Luca Santarelli Chief Executive Officer VectivBio Holding AG Aeschenvorstadt 36 4051 Basel Switzerland Re: VectivBio Holding AG Registration Statement on Form F-3 Filed May 4, 2022 File No. 333-264653 Dear Mr. Santarelli: This is to advise you that we have not reviewed and will not review your registration statement. Please refer to Rules 460 and 461 regarding requests for acceleration. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Please contact Daniel Crawford at 202-551-7767 with any questions. Sincerely, Division of Corporation Finance Office of Life Sciences cc: Brandon Fenn, Esq.